News Releases
| Day | Date | Opponent | Location | TV | Outcome/Time |
| Thu | 08/31/2000 | SE Missouri State (Youth Day) | Huntington, W. Va. | | W, 63-7 |
| Sat | 09/09/2000 | at Michigan State | East Lansing, Mich. | | L, 34-24 |
| Sat | 09/23/2000 | at North Carolina | Chapel Hill, N.C. | | L, 20-15 |
| Sat | 09/30/2000 | Buffalo (Band Day) | Huntington, W. Va. | | W, 47-14 |
| Thu | 10/05/2000 | Western Michigan | Huntington, W. Va. | ESPN | L, 30-10 |
| Sat | 10/14/2000 | at Toledo | Toledo, Ohio | | L, 42-0 |
| Sat | 10/21/2000 | Kent State (Homecoming) | Huntington, W. Va. | | W, 34-12 |
| Sat | 10/28/2000 | at Akron | Akron, Ohio | | W, 31-28 |
| Sat | 11/04/2000 | at Bowling Green | Bowling Green, Ohio | | W, 20-13 |
| Sat | 11/11/2000 | Miami (OH) | Huntington, W. Va. | | W, 51-31 |
| Sat | 11/18/2000 | at Ohio | Athens, Ohio | | L, 38-28 |
| Sat | 12/02/2000 | Western Michigan (MAC Championship) | Huntington, W. Va. | ABC | W, 19-14 |
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